目的：观察肾病综合征患儿血清铜、锌、铁含量。方法：采用原子吸收分光光度法测定肾病综合征患儿血清铜、锌、铁，并与正常对照组进行比较。结果：肾病综合征患儿血清铜、锌均低于正常组（Ｐ＜００１），血清铁略低于正常对照组，无显著性差异（Ｐ＞００５）。同时测定了３１例肾病综合征患儿经治疗尿蛋白转阴后血清铜、锌、铁含量，其中血清锌为１１２μｍｏｌ／Ｌ，较治疗前升高，且有极显著性差异（Ｐ＜００１），血清铜、铁与治疗前比较无显著差异（Ｐ＞００５）。结论：血清白蛋白的减少是肾病综合征患儿血清铜、锌含量降低的一个重要原因 Objective: To observe the contents of serum copper, zinc and iron in children with nephrotic syndrome. Methods: Serum copper, zinc and iron in children with nephrotic syndrome were determined by atomic absorption spectrophotometry and compared with normal control group. Results: Serum copper and zinc in children with nephrotic syndrome were lower than those in normal group (P <001) and serum iron slightly lower than those in normal control group (P> 0.05). The contents of serum copper, zinc and iron in 31 children with nephrotic syndrome were measured. The serum zinc was 112 μmol / L, which was significantly higher than that before treatment (P < 0  01), serum copper, iron and no significant difference between before treatment (P> 0  05). Conclusion: The decrease of serum albumin is an important reason for the decrease of serum copper and zinc in children with nephrotic syndrome