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1985年,Stetler等根据美国疾病控制中心(CDC)接种疫苗后不良反应监测系统(MSAEFI)1979～1982年的资料,指出以往有过惊厥史的婴幼儿接种DTP后发生神经系统反应的危险性增加7.2倍,因此,美国免疫实施咨询委员会(ACIP)等建议有惊厥史的儿童可以推迟到确定无进行性神经系统疾病时接种百日咳菌苗.如果发现有进行性神经系统疾病,应禁忌接种百日咳菌苗,但应按现在程序给予全程的白喉和破伤风类毒素混合
In 1985, Stetler et al. (1979-1982) based on data from the MSAEFI (Vaccine Adverse Events Monitoring System) of the CDC pointed out that in infants and young children with a history of seizures, the risk of nervous system reaction increased after DTP 7.2 times, therefore, children with a history of convulsions, such as ACIP, may postpone vaccination of pertussis vaccine when it is determined that there is no progressive neurological disease.If there is a progressive neurological disease, whooping cough should be contraindicated Seedlings, however, should be given the current program of diphtheria and tetanus toxoid mixture