Objectives To investigate therelationship between plasma adiponectin level andcoronary heart disease (CHD), and some establishedcardiovascular risk factors and to probe its probablepathogenesis which adiponectin results in CHD.Methods The levels of plasma adiponectin, fastingplasma insulin (FINS), C-reactive protein (CRP) andP-selectin were measured by ELISA, plasma ET-1 wasmeasured by radioimmunoassay (RIA) in 75 malepatients with CHD and 30 healthy male people. Bodymass index (BMI), waist / hip ratio (WHR) andinsulin resistance index (Homa-IR) were calculatedrespectively. Results (1)The plasma adiponectinlevels in CHD group were lower compared with controlgroup[(5.18±2.57)mg / L vs(8.94±2.59)mg / L, P<0.001 ], there was no significant difference of plasmaadiponectin levels in CHD sub-groups (P > 0.05).(2)Based on multinominal stepwise logistic regressionanalysis, adiponectin was one of significant andindependent risk factors for CHD.(3) Multivariate linerstepwise regression analysis showed that adiponectinhad significant correlation with BMI and TG, BMI andTG were independent factors influencing on plasmaadiponectin levels. (4) Pearson correlation analysisindicated plasma adiponectin levels were inverselyrelated to FINS levels , Homa-IR, CRP, P-selectinand ET-1. Conclusions (1)Plasma adiponectinlevels are lower in CHD patients compared the controlsubjects. there are no significant difference of plasmaadiponectin levels in patients with SAP, UAP andAMI. (2) Plasma adiponectin levels are relative withCHD. Hypoadiponectinemia is an independent riskfactor for CHD. (3)Established cardiovascular riskfactors such as BMI and TG have an obvious influenceon adiponectin. (4)The probable pathogenesis by whichadiponectin involves in CHD is suggested thatadiponectin relates to insulin resistance, inflammatoryreaction and dysfunction of vessel endothelium. Objectives To investigate therelationlationbetween plasma adiponectin level andcoronary heart disease (CHD), and some establishedcardiovascular risk factors and to probe its probablepathogenesis which adiponectin results in CHD. Methods The levels of plasma adiponectin, fastingplasma insulin (FINS), C-reactive protein ) and P-selectin were measured by ELISA, plasma ET-1 wasmeasured by radioimmunoassay (RIA) in 75 malepatients with CHD and 30 healthy male people. Body mass index (BMI), waist / hip ratio (WHR) andinsulin resistance index Results (1) The plasma adiponectinlevels in CHD group were lower compared with controlgroup [(5.18 ± 2.57) mg / L vs (8.94 ± 2.59) mg / L, P <0.001], there was no significant difference of plasmaadiponectin Levels in CHD sub-groups (P> 0.05). (2) Based on multinominal stepwise logistic regression analysis, adiponectin was one significant and in dependent risk factors for CHD. (3) Multivariate line rstepwise regression analysi s showed that adiponectinhad significant correlation with BMI and TG, BMI and TG were independent factors influencing on plasmaadiponectin levels. (4) Pearson correlation analysisindicated plasma adiponectin levels were inversely correlated to FINS levels, Homa-IR, CRP, P-selectin and ET-1. (1) Plasma adiponectinlevels are lower in CHD patients than the controlsubjects. There are no significant differences of plasmaadiponectin levels in patients with SAP, UAP and AMI. (2) Plasma adiponectin levels are relative with CHD. Hypoadiponectinemia is an independent risk factor for CHD. (3 ) Established cardiovascular risk factors such as BMI and TG have an obvious influence on adiponectin. (4) The probable pathogenesis by whichadiponectin involves in CHD is suggested thatadiponectin relates to insulin resistance, inflammatory reaction and dysfunction of vessel endothelium.