核因子-κB(NF-κB)是近年来研究极为广泛的转录调控因子,具有多种转录调节活性。参与细胞因子、活化因子、生长因子和粘附分子及某些急性期反应蛋白转录活性的调控,在正常及疾病状态下、在肿瘤的发生和发展过程中有重要作用。NF-κB在肝细胞、肝癌细胞都有表达,在肝移植、肝缺血再灌注损伤等病理生理过程中均发挥重要作用。 Nuclear factor-κB (NF-κB) is a very widely studied transcriptional regulator in recent years with a variety of transcriptional regulatory activities. Participation in the regulation of cytokines, activators, growth factors and adhesion molecules and the transcriptional activity of some acute phase reaction proteins plays an important role in the development and progression of tumors in normal and disease states. NF-κB is expressed in hepatocytes and hepatoma cells, and plays an important role in pathophysiological processes such as liver transplantation and hepatic ischemia-reperfusion injury.