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自从认识了一些药物可刺激或抑制血红素前体物转变为血红素以来,血红素生物合成途径已引起人们的重视。现已知有些金属在血红素生物合成过程中起着重要作用,有些金属则有毒性作用。近来,对血红素破坏过程进行了很多研究,对血红素的分解代谢系统的作用也需要了解。已知在血液中或其他组织中,ALA脱水酶的活性显然受铅的抑制,以至在铅中毒时血和尿中ALA增加。锌可保持ALA脱水酶的活性,故它可改变铅对该酶的某些作用。血红素的形成需要血红素合成酶(亚铁螯合酶)和
Since recognizing that some drugs can stimulate or inhibit the conversion of heme precursors to heme, the heme biosynthesis pathway has drawn much attention. It is known that some metals play an important role in heme biosynthesis, while others are toxic. Recently, much research has been done on the process of heme destruction, and the role of heme catabolism systems needs to be understood. It is known that the activity of ALA dehydratase in blood or other tissues is apparently inhibited by lead, leading to an increase in ALA in blood and urine during lead poisoning. Zinc can maintain ALA dehydratase activity, so it can change some of the role of lead on the enzyme. The formation of heme requires heme synthase (ferrous chelatase) and