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目的评价HPV检测对无EC/TZS成分、涂片阴性的妇女中进行疾病风险评估的价值。方法我们对2009年1月和2012年1月44192例宫颈液基结果进行回顾性分析。依据年龄和有无EC/TZ成分对低度鳞状上皮内瘤变(LSIL)和高度鳞状上皮内瘤变(HSIL)进行分组,对高危型人乳头状瘤病毒(hrHPV)DNA检出率进行比较。结果共44192份子宫颈涂片标本,有EC/TZ及无EC/TZ所占比例分别为62.87%、37.13%;整体LSIL检出率为0.78%,HSIL检出率为0.32%。在44192份样本中,总体比较,有EC/TZ组LSIL(P<0.001)、HSIL(P<0.001)检出率高于无EC/TZ组,差异显著;在LSIL组,各年龄段间,以及总体比较,有EC/TZ组HPV检出率与无EC/TZ组无显著差异(P=0.125)。在HSIL组,总体比较,有EC/TZ组HPV检出率与无EC/TZ组无显著差异(P=0.438)。即LSILs和HSILs妇女按照EC/TZS进行分组后,hrHPV检出率没有显著的差异。结论 hrHPV DNA检测对有或无EC/TZS妇女可进行客观有效的分层,是对无EC/TZS成分、涂片阴性的妇女进行疾病风险评估的有用的辅助工具。
Objective To evaluate the value of HPV testing in the assessment of disease risk in women with no EC / TZS component and smear negative. Methods We retrospectively analyzed 44,192 cervical fluid-based findings in January 2009 and January 2012. Low grade squamous intraepithelial neoplasia (LSIL) and high grade squamous intraepithelial neoplasia (HSIL) were grouped according to age and presence of EC / TZ components, and the detection rate of high-risk human papillomavirus (hrHPV) DNA Compare. Results A total of 44192 cervical smears with EC / TZ and no EC / TZ accounted for 62.87% and 37.13% respectively. The overall detection rate of LSIL was 0.78% and the detection rate of HSIL was 0.32%. Among the 44,192 samples, the overall detection rate of LSIL (P <0.001) and HSIL (P <0.001) in EC / TZ group was higher than that in non-EC / TZ group Overall, there was no significant difference in the detection rate of HPV between EC / TZ group and non-EC / TZ group (P = 0.125). In the HSIL group, there was no significant difference (P = 0.438) between the detection rate of HPV in EC / TZ group and the control group without EC / TZ. There was no significant difference in the detection rate of hrHPV between women with LSILs and HSILs grouped according to EC / TZS. Conclusion The hrHPV DNA test provides an objective and effective stratification for women with or without EC / TZS and is a useful adjunct to disease risk assessment for women who do not have an EC / TZS component, smear negative.