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目的:探讨产后出血患者大量输血治疗时血浆和红细胞的比例对凝血功能的影响。方法:收治产后大出血患者30例,随机分为低血浆组(血浆:红细胞=1:2.5)、中血浆组(血浆:红细胞=1:1)和高血浆组(血浆:红细胞=1.5:1)。每2 h检测1次凝血功能及血常规,以便调整输血治疗方案。结果:大量输血后24 h,低血浆组凝血功能指标及血小板、血红蛋白与输血前比较,差异有统计学意义(P<0.05),中血浆组和高血浆组血小板、血红蛋白明显低于产前(P<0.05),而中血浆组血小板、血红蛋白明显高于低血浆组和高血浆组(P<0.05)。结论:产后大出血患者输血时,选择血浆:红细胞=1:1的输注方案为最佳。
Objective: To investigate the effect of the ratio of plasma and erythrocyte on the coagulation function in patients with postpartum hemorrhage undergoing massive blood transfusion. Methods: Thirty patients with postpartum hemorrhage were randomly divided into low plasma group (plasma: erythrocyte = 1: 2.5), medium plasma group (erythrocyte = 1: 1) and high plasma group . Blood coagulation and blood tests were performed every 2 hours to adjust the transfusion regimen. Results: At 24 h after massive blood transfusion, the indexes of coagulation function, platelet and hemoglobin in low plasma group were significantly different from those before transfusion (P <0.05), while the platelets and hemoglobin in middle plasma and high plasma were significantly lower than those of prenatal P <0.05), while the platelet and hemoglobin in middle plasma were significantly higher than those in low plasma and high plasma (P <0.05). CONCLUSIONS: In the case of blood transfusions in patients with postpartum hemorrhage, the best choice is the transfusion protocol with plasma: erythrocyte = 1: 1.