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目的探讨纳米氧化锌(nano-ZnO)在抗紫外线辐射(Ultraviolet radiation,UVR)所致皮肤损伤中的作用。方法正常豚鼠24只,随机均分为纳米氧化锌干预组、基质组和自身对照组,皮肤在纳米氧化锌干预下经过量UVR后,对其皮肤切片进行苏木精-尹红染色(HE)、胶原纤维染色(VG)和过碘酸-雪夫反应染色(PAS)染色,肉眼和光镜观察皮肤组织变化,并作组间比较。结果与自身对照组组织比较,纳米氧化锌干预组皮肤未发生明显的肉眼和镜下组织学改变;同样条件下,对各组豚鼠皮肤切片进行HE、VG和PAS染色比较,基质对照组表层及皮下组织结构均有相应明显改变。结论纳米氧化锌具有良好的抗紫外线所致皮肤损伤特性。
Objective To investigate the role of nano-ZnO in the skin damage caused by ultraviolet radiation (UVR). Methods Twenty-four normal guinea pigs were randomly divided into two groups: namoxifen intervention group, matrix group and self-control group. The skin of the guinea pigs were exposed to nano-zinc oxide and subjected to UVR. , Collagen fiber staining (VG) and periodic acid-Schiff reaction staining (PAS) staining. The changes of skin tissues were observed by naked eye and light microscope, and compared between groups. Results Compared with their own control group, there was no obvious macroscopic and microscopic histological changes in the skin of the rats treated with nano-ZnO. Under the same conditions, HE staining, VG staining and PAS staining of skin sections of guinea pigs were compared. Subcutaneous tissue structure has been significantly changed accordingly. Conclusion Zinc oxide has a good UV-induced skin damage characteristics.