论文部分内容阅读
目的评价国产醋酸奥曲肽治疗肝硬化食管胃底静脉曲张破裂出血的临床疗效。方法64例食管胃底静脉曲张破裂出血患者随机分成两组,治疗组首次静脉推注国产醋酸奥曲肽0.1 mg,继以0.05 mg/h连续静脉滴注72～96 h对照组给予垂体后叶素0.2～0.4u/min持续静脉滴注72～96h,高龄或伴有冠心病患者联合应用硝酸甘油0.8 mg/h,观察2组的止血率及不良反应。结果治疗组止血率为93.8%,不良反应率为9.7%,对照组止血率为53.6%,不良反应率为42.2%,两组止血率及不良反应率差异有统计学意义(P<0.01)。结论国产醋酸奥曲肽治疗食管胃底静脉曲张破裂出血的疗效明显高于垂体后叶素,且不良反应少,有很高的临床价值。
Objective To evaluate the clinical efficacy of domestic octreotide acetate in the treatment of patients with esophageal and gastric variceal bleeding due to cirrhosis. Methods Sixty-four patients with esophageal variceal bleeding were randomly divided into two groups. The treatment group received the first intravenous injection of domestic octreotide acetate 0.1 mg, followed by continuous intravenous infusion of 0.05 mg / h for 72-96 h. The control group was given pituitrin 0.2 ~ 0.4u / min continuous intravenous infusion 72 ~ 96h, elderly or patients with coronary heart disease combined with nitroglycerin 0.8 mg / h, the two groups were observed hemostasis and adverse reactions. Results The rate of hemostasis was 93.8% in the treatment group, 9.7% in the adverse reaction rate, 53.6% in the control group and 42.2% in the control group. There was significant difference between the two groups in the rate of hemostasis and adverse reaction (P <0.01). Conclusion The efficacy of domestic octreotide acetate in the treatment of esophageal variceal bleeding was significantly higher than that of pituitrin with less adverse reactions and high clinical value.