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目的采用正交试验筛选异烟肼巴布剂的处方。方法以膜残留和涂展性为评价指标进行正交试验,确定最佳处方。结果异烟肼巴布剂处方组成是主药异烟肼∶黏着剂(质量比是1∶3的卡波姆∶NP700)∶保湿剂(甘油)∶交联剂(甘羟铝)=3∶6∶30∶0.1。结论异烟肼巴布剂处方设计较为合理,可进一步开发。
Objective To test the prescription of isoniazid poultice by orthogonal test. Methods The membrane residual and spreadability as the evaluation index for orthogonal test to determine the best prescription. Results The formulation of isoniazid poultice was composed of isoniazid: adhesive (carbomer: NP700 in mass ratio of 1: 3): humectant (glycerol): cross-linking agent 6:30:0.1. Conclusion The formulation of isoniazid poultice prescription is reasonable and can be further developed.