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比较不同月龄小鼠学习记忆力与脑内突触结构参数变化的相关性。选用１月龄和６月龄小鼠，用Ｙ－迷宫检测分辨学习能力，用一次性被动回避反应检测记忆力。然后杀鼠取脑，进行超微结构观察和定量分析测定。结果表明：（１）１月龄小鼠的分辨学习能力优于６月龄小鼠，记忆力也有优于６月龄小鼠的趋势。（２）无论在海马或大脑皮层体区，有两种结构参数有一致性增龄变化，即６月龄小鼠突触界面曲率都比１月龄小鼠显著和极显著增大；而６月龄小鼠上述两脑区的突触后致密物质厚度都极显著地小于１月龄小鼠。实验结果提示，脑内突触界面结构的增龄性变化可能是学习记忆力增龄性变化的结构基础。
The correlation between learning and memory ability and changes of synaptic structural parameters in different age mice was compared. Selection of 1-month-old and 6-month-old mice, Y-maze test to distinguish learning ability, with a one-time passive avoidance test to detect memory. Then killing rats and brain, the ultrastructure observation and quantitative analysis determination. The results showed that: (1) 1-month-old mice had better discrimination learning ability than 6-month-old mice, and their memory was superior to that of 6-month-old mice. (2) There are two kinds of structural parameters in the hippocampus or cerebral cortex body regions, which have the same age-related changes, that is, the synaptic interface curvature of 6-month-old mice is significantly and extremely significantly increased compared with that of 1-month-old mice; The thickness of postsynaptic dense material in the two brain regions of the mice of the age were significantly less than that of the mice of 1 month old. The experimental results suggest that the age-related changes of synaptic interface structure in brain may be the structural basis of learning and memory age-related changes.