一般认为有效循环血量不足、肾血流动力学异常是重症急性胰腺炎并发肾功能障碍的主要原因 ,近年研究发现重症急性胰腺炎时体内高浓度的炎症介质、细胞因子 ,以及腹腔间隔室综合征、腹腔炎性渗液等也是参与其发生的重要因素 ,在炎症介质细胞因子的防治中作用也日益受到重视。本文就近年来重症急性胰腺炎发病机制、早期预防和相应治疗对策等方面的进展综述如下。 Generally believed that the lack of effective circulating blood volume, renal hemodynamic abnormalities is the main cause of severe acute pancreatitis complicated by renal dysfunction in recent years found that severe acute pancreatitis in vivo high concentrations of inflammatory mediators, cytokines, and the abdominal compartment synthesis Symptoms, peritoneal inflammatory exudate is also an important factor involved in its occurrence, the role of inflammatory cytokines in the prevention and treatment are also increasingly valued. In this paper, in recent years, the pathogenesis of severe acute pancreatitis, early prevention and the corresponding treatment and other aspects of progress are summarized below.