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胰岛素抵抗(Insulin Resistance,IR)是机体对胰岛素作用不敏感现象,表现为胰岛素促进外周组织肌肉、脂肪摄取和利用葡萄糖以及抑制肝葡萄糖输出的效应减弱,需要分泌更多的胰岛素才能代偿。目前全世界约有5%的人口存在IR,且随着社会的发展,生活水平的提高,IR的发生率将越来越高。IR是非常重要的病理生理现象,与肥胖、糖尿病、心血管疾病及肿瘤等多种疾病相关。自20世纪90年代以来,IR已成为世界医学界关注的前沿性课题。
Insulin resistance (IR) is the body’s role in the insulin-insensitive phenomenon, manifested as insulin to promote peripheral muscle, fat intake and utilization of glucose and inhibit the effect of hepatic glucose output weakened, the need to secrete more insulin to compensate. At present, about 5% of the world’s population has IR, and with the development of society and improvement of living standards, the incidence of IR will be higher and higher. IR is a very important pathophysiological phenomenon associated with various diseases such as obesity, diabetes, cardiovascular diseases and tumors. Since the 1990s, IR has become the forefront topic of concern in the world medical community.