在抗放药物临床过渡中,常选择某些肿瘤放疗病人进行研究,如食道癌、宫颈癌和乳腺癌等。其照射条件与通常放射生物实验的动物照射有以下两点不同:(1)长时间的多次照射;(2)小射野局部照射。在这种放疗条件下,射线对病人全身引起多大的损伤,即一次全身等效剂量多大,这是药物过渡工作十分关心的问题之一。关于多次照射归一到一次照射剂量方法,文献报导很多。 In the clinical transition of anti-radiation drugs, some patients with tumor radiotherapy are often selected for research, such as esophageal cancer, cervical cancer, and breast cancer. The irradiation conditions are different from those of conventional radiation biology experiments in the following two points: (1) multiple exposures over a long period of time; (2) local irradiation of small fields. Under such radiotherapy conditions, how much damage is caused to the patient’s whole body by radiation, that is, how much a systemic equivalent dose is, which is one of the issues that the drug transition work is very concerned about. There are many reports in the literature on the method of multiple exposures normalized to one dose.