论文部分内容阅读
【目的】探讨0~10岁儿童维持正常骨代谢的最佳25羟-维生素D[25-(OH)D]水平,为临床评估维生素D营养状况和合理使用维生素D制剂提供参考。【方法】以142名0~10岁健康和患呼吸系感染性疾病儿童为研究对象,抽取空腹静脉血检测血清中甲状旁腺激素(PTH)、骨碱性磷酸酶(BAP)、25-(OH)D、血钙、血磷的水平。通过分析25-(OH)D与甲状旁腺激素(PTH)、骨碱性磷酸酶(BAP)、钙磷浓度积(Ca×P)的量-量反应曲线确定维持正常骨代谢的最佳25-(OH)D水平。【结果】25-(OH)D与PTH、BAP的量-量反应曲线显示,在25-(OH)D≤50nmol/L时,PTH、BAP和25-(OH)D水平均显著相关(rPTH=-0.864,P<0.01;rBAP=-0.856,P<0.01),50 nmol/L<25-(OH)D<60 nmol/L时,血清PTH、BAP保持在一稳定水平。25-(OH)D与钙磷浓度积(Ca×P)的量-量反应曲线显示,25-(OH)D≤50nmol/L时,钙磷浓度积随25-(OH)D水平增加而增高,但相关分析显示两者无显著相关关系(r=0.037,P>0.05)。在50nmol/L<25-(OH)D<60 nmol/L时,钙磷浓度积保持在一较稳定水平。【结论】南京市0~10岁年龄段儿童中,血清25-(OH)D水平在50~60 nmol/L时可能是维持正常骨代谢的最佳浓度。
【Objective】 To investigate the optimal 25-hydroxyvitamin D [25- (OH) D] level in children with 0-10 years old to maintain normal bone metabolism and provide a reference for clinical assessment of nutritional status of vitamin D and rational use of vitamin D preparations. 【Methods】 A total of 142 children aged 0-10 years with healthy and respiratory infectious diseases were enrolled in this study. Fasting venous blood samples were collected for determination of serum parathyroid hormone (PTH), bone alkaline phosphatase (BAP), 25- ( OH) D, blood calcium, phosphorus levels. The best 25 for maintaining normal bone metabolism was determined by analyzing the amount-response curves of 25- (OH) D and PTH, BAP and CaxP - (OH) D level. 【Results】 The results showed that the levels of 25- (OH) D, PTH and BAP showed a significant correlation with the levels of 25- (OH) D (PTH, BAP and 25- (OH) D) = -0.864, P <0.01; rBAP = -0.856, P <0.01). The serum PTH and BAP remained at a steady level when 50 nmol / L <25- (OH) D <60 nmol / L. The quantity-response curves of 25- (OH) D and Ca (P × P) showed that the concentration of calcium and phosphorus increases with the increase of 25- (OH) D when 25- (OH) D≤50nmol / But the correlation analysis showed no significant correlation (r = 0.037, P> 0.05). At 50 nmol / L <25- (OH) D <60 nmol / L, the concentration of calcium and phosphorus remained at a relatively stable level. 【Conclusions】 Serum 25- (OH) D level of 50-60 nmol / L in children aged 0-10 years in Nanjing may be the best concentration for maintaining normal bone metabolism.