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选用清洁级Wistar大鼠40只,雌雄各半,分为4组,以25mg/(kg.d)丙烯酰胺(acrylamide,ACR)为染毒组,大豆异黄酮(soybean isoflavone,SI)高、低剂量组在大鼠染毒的同时灌胃大豆异黄酮50、25mg/(kg.d),正常对照组以等量蒸馏水灌胃,连续灌胃4周后,颈椎脱臼处死大鼠立即取小脑组织,进行过氧化物指标检测和形态学观察。结果染毒组和正常对照组之间差异有统计学意义(P<0.05),而对照组与大豆异黄酮高剂量组则差别不大(P>0.05)。ACR能够引起大鼠小脑的损伤,而SI可能对ACR的神经毒作用有一定的拮抗作用。
Forty clean Wistar rats were selected and divided into 4 groups according to male and female. The rats were exposed to 25 mg / (kg.d) acrylamide (ACR), and soybean isoflavone (SI) The dose group was intragastrically administered with soy isoflavones 50 and 25 mg / (kg · d) at the same time. The rats in the normal control group were given gavage with equal volume of distilled water. After continuous gavage for 4 weeks, the rats were killed immediately after cervical dislocation , Peroxide indicators detection and morphological observation. Results The difference between the control group and the normal control group was statistically significant (P <0.05), while there was no significant difference between the control group and the high-dose soy isoflavone group (P> 0.05). ACR can cause damage to the cerebellum of rats, and SI may have some antagonism on the neurotoxic effect of ACR.