目的:探讨妊娠与非妊娠妇女下生殖道感染状况。方法:随机选取常规围产期保健妇女180例(早期妊娠60例、中期妊娠60例、晚期妊娠60例)采集阴道分泌物,测定pH值,检测外阴阴道假丝酵母菌病、滴虫性阴道炎、细菌性阴道病,宫颈分泌物,利用DNA杂交导流技术检测人乳头瘤病毒(HPV)及基因分型。选择60例非妊娠期健康妇女进行相同的检查作为对照。结果:阴道pH值在妊娠各期均低于非妊娠期(P<0.01)。妊娠期细菌性阴道病(BV)、外阴阴道假丝酵母菌病(VVC)及HPV感染率分别是19.4%、21.7%、28.9%,非妊娠期三项感染率分别为8.3%、10.0%、15.0%,妊娠期高于非妊娠期妇女(P<0.05)。不同妊娠期别HPV感染率及基因亚型不同,妊娠晚期HPV感染率最高,达46.7%,明显高于早、中妊娠期HPV感染率(P<0.05)。妊娠妇女高危型HPV感染率高于非妊娠妇女,以妊娠晚期明显,且部分伴有多重型感染。结论:妊娠期妇女下生殖道感染发生率高,尤应注意HPV感染,需要重复检测,加强随访。 Objective: To investigate the genital tract infection in pregnant and non-pregnant women. Methods: 180 cases of normal perinatal women were randomly selected (60 cases of early pregnancy, 60 cases of middle-term pregnancy and 60 cases of late pregnancy). Vaginal secretions were collected and the pH value was measured. Vulvovaginal candidiasis, Inflammation, bacterial vaginosis, cervical secretions, detection of human papillomavirus (HPV) and genotyping by DNA hybridization. 60 healthy non-pregnant women were selected for the same examination as a control. Results: Vaginal pH was lower in all stages of gestation than in non-gestation period (P <0.01). The prevalences of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC) and HPV infection during pregnancy were 19.4%, 21.7% and 28.9%, respectively. The rates of infection in non-gestation period were 8.3%, 10.0% 15.0% in pregnancy than in non-pregnant women (P <0.05). In different pregnancy rates of HPV infection and genotypes, HPV infection rate was the highest in late pregnancy (46.7%), which was significantly higher than that of HPV infection in early and middle gestation (P <0.05). The prevalence of high-risk HPV in pregnant women is higher than that in non-pregnant women, which is obvious in the third trimester of pregnancy, and some are associated with multiple infections. Conclusion: The incidence of lower genital tract infection in pregnant women is high, especially HPV infection should be paid attention to. Repeat testing and follow-up are needed.