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目的 :探讨系统性红斑狼疮 ( SL E)患者血凝象改变及免疫吸附治疗对 SL E凝血象的影响 ,为临床治疗提供依据。方法 :用 ACL 2 0 0型全自动血凝分析仪测定凝血及纤溶 ,用发色底物法测组织型纤溶酶激活物 ( t-PA)和纤溶酶激活物抑制物 ( PAI-1 )。结果 :SLE患者 FIB、PT、APTT、TT、AT- 出现多种组合形式异常 ;t-PA及 PAI-1活性均增强 ,治疗后 SLE患者部分 APTT恢复正常 ,AT- 活性升高。结论 :综合检测 SLE血凝指标 ,可指导治疗。
Objective: To investigate the effect of blood coagulation changes and immunoadsorption therapy on blood coagulation in SL E in patients with systemic lupus erythematosus (SL E), and to provide basis for clinical treatment. Methods: The blood coagulation and fibrinolysis were determined by ACL 200 automated coagulation analyzer. The levels of t-PA and PAI- 1 ). Results: There were various combinations of FIB, PT, APTT, TT and AT- in patients with SLE. The activity of both t-PA and PAI-1 were increased. Some APTT in SLE patients returned to normal and the AT-activity increased after treatment. Conclusion: Comprehensive detection of SLE coagulation index can guide the treatment.