Aim: To describe use of vasopressin infusion for catecholamine-refractory septic shock in children. Methods: We report successful use of vasopressin infusion in three children with septic shock, in whom hypotension and poor perfusion persisted despite use of multiple infusions of vasopressors and inotropes. Results: All three had a rapid improvement in hypotension and perfusion after starting vasopressin infusion, allowing tapering of other infusions. Two children recovered completely. Conclusions: Vasopressin appears to be useful in treatment of catecholamine-refractory septic shock in children. Aim: To describe use of vasopressin infusion for catecholamine-refractory septic shock in children. Methods: We report successful use of vasopressin infusion in three children with septic shock, in whom hypotension and poor perfusion persisted despite use of multiple infusions of vasopressors and inotropes. Results: All three had a rapid improvement in hypotension and perfusion after starting vasopressin infusion, allowing tapering of other infusions. Two children recovered completely. Conclusions: Vasopressin appears to be useful in treatment of catecholamine-refractory septic shock in children.