妇女在妊娠和哺乳期间使用药物治疗是否对胎儿和新生儿有影响,这是临床科室和药剂人员经常遇到的问题。十三年前作者曾就这一问题作过综述。随着医药科学研究的不断深入,有关这方面的国外资料不断增加,近年来国内书刊也有介绍,但总的来看,我国在这方面的研究还很不够。现将搜集到的部分资料,再作一概括介绍。妊娠期间用药对胎儿的影响一、药物的胎盘转运在妊娠期间母体用药一定要通过胎盘的转运才能到达胎儿体内。决定药物胎盘转运的因素可从药物与胎盘两方面考虑。从药物方面来讲:由于胎盘屏障像血脑屏障一 Whether women use drugs during pregnancy and breastfeeding affects fetuses and newborns is a problem that clinicians and pharmacy workers often encounter. Thirteen years ago the author reviewed this issue. With the continuous deepening of medical scientific research, the foreign materials in this field are constantly increasing. In recent years, domestic books and periodicals have also been introduced. However, on the whole, our research in this field is not enough. Some of the information we will collect will be briefly introduced. The impact of medication on the fetus during pregnancy First, the drug’s placental transport During pregnancy, maternal medication must be transported through the placenta in order to reach the fetus. The factors that determine the transport of drug placenta can be considered both in medicine and placenta. From a drug point of view: due to the placental barrier like a blood-brain barrier