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目的研究产妇围产期乙肝感染状态与脐带血和新生儿免疫状态之间的关系,为临床新生儿疾病预测相关研究提供借鉴参考。方法选取2012年12月-2013年12月医院出生的新生儿88例为研究对象,根据新生儿母亲是否感染乙肝病毒分为感染组和对照组,各44例;比较两组新生儿临床指标。结果感染组新生儿CD3+和CD4~+水平、IgA和IgM指标均显著高于对照组,感染组新生儿CD19+水平为(9.54±4.32)%,显著低于对照组;感染组新生儿病死率、乙肝感染率、肺部感染率和黄疸发生率分别为11.36%、45.45%、31.82%和13.64%均显著高于对照组,两组比较差异均有统计学意义(P<0.05)。结论围产期产妇感染乙肝病毒可以对新生儿脐带血中免疫因子、淋巴细胞亚群等产生影响,针对新生儿脐带血的监测有助于对新生儿免疫疾病发生情况进行预测。
Objective To study the relationship between hepatitis B infection status and immune status of umbilical cord blood and neonates during perinatal period and to provide references for the research on the prediction of clinical neonatal diseases. Methods Eighty-eight newborns born in the hospital from December 2012 to December 2013 were selected as study subjects, divided into infection group and control group according to whether the new-born mother was infected with hepatitis B virus (HBV) and control group (44 cases each). Clinical indexes of two groups were compared. Results The neonatal CD3 + and CD4 + levels, IgA and IgM in infected group were significantly higher than those in control group. The level of CD19 + in neonates with infection was (9.54 ± 4.32)%, which was significantly lower than that in control group. The neonatal mortality, The infection rate of hepatitis B, incidence of pulmonary infection and incidence of jaundice were 11.36%, 45.45%, 31.82% and 13.64%, respectively, which were significantly higher than those of the control group. There was significant difference between the two groups (P <0.05). Conclusion Perinatal maternal infection with hepatitis B virus may have effects on immune factors and lymphocyte subsets of cord blood in neonates. The monitoring of neonatal cord blood is helpful to predict the occurrence of neonatal immune diseases.