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目的:观察声门癌及癌旁组织中SKP2及MRP-1/CD9蛋白的变化意义及其对声门癌手术安全切除范围的指导意义。方法:用免疫组织化学SP法检测38例声门鳞状细胞癌组织及距癌组织边缘2、5、10mm的组织中SKP2及MRP-1/CD9蛋白的表达,并取10例声带息肉组织作对照。结果:SKP2蛋白产物异常表达按息肉黏膜组织、癌旁组织(2、5、10mm)及癌组织的顺序依次递减,差异有统计学意义(均P<0.05);MRP-1/CD9蛋白产物异常表达按息肉黏膜组织、癌旁组织(2、5、10mm)及癌组织的顺序依次递增,差异有统计学意义(均P<0.05)。结论:SKP2及MRP-1/CD9均可作为判断喉癌生物学特性的参考指标,声门癌手术安全切缘以距肿瘤≥5mm的标准较为适宜。
Objective: To observe the significance of the changes of SKP2 and MRP-1 / CD9 proteins in the gliomas and paracancerous tissues and their implications for the safety of glottic cancer resection. Methods: The expressions of SKP2 and MRP-1 / CD9 protein in 38 cases of glottis squamous cell carcinoma and 2, 5 and 10 mm away from the edge of cancer tissues were detected by immunohistochemical SP method. Ten cases of vocal cord polyps Control. Results: Abnormal expression of SKP2 protein decreased in the order of polyp mucosa, paracancerous tissues (2, 5, and 10 mm) and cancerous tissues (all P <0.05); the abnormalities of MRP-1 / CD9 protein According to the order of polyp mucosa tissues, paracancerous tissues (2, 5, 10mm) and cancerous tissues, the order of increase was statistically significant (all P <0.05). Conclusion: Both SKP2 and MRP-1 / CD9 can be used as a reference index to judge the biological characteristics of laryngeal cancer.