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目的:观察和分析对比干预前、后我院Ⅰ类切口手术预防用抗菌药物的合理性,考察干预措施的实施效果。方法:选择广州中医药大学附属骨伤科医院2013年1-6月164例出院Ⅰ类切口手术患者设为对非干预照组,2013年7月-12月179例出院Ⅰ类切口手术患者设为干预观察组,对比两组Ⅰ类切口手术预防用抗菌药物的合理性。结果:干预后,Ⅰ类切口手术预防用药在药物选择上抗菌药物应用率下降了20.35%,第3代头孢菌素应用率下降了41.26%,第1代头孢菌素应用率提高了11.67%。初次用药时机在术前0.5~2 h的比例提高了36.57%;术后用药时间≤48 h的比例提高了38.76%,差异具有统计学意义(P<0.05)。结论:我院通过采用有效的干预措施,可以确保我院患者合理、安全地使用抗菌药物。
OBJECTIVE: To observe and analyze the rationality of antimicrobial agents used in class Ⅰ surgical incision in our hospital before and after intervention, and investigate the effect of interventions. Methods: One hundred and sixty-four cases of discharged type Ⅰ incision in January-June 2013 from Guangzhou General Hospital of Orthopedics and Traumatology of Guangzhou University of Traditional Chinese Medicine were enrolled as non-intervention group and 179 cases of type Ⅰ incision surgery from July 2013 to December 2013 For the intervention group, we compared the rationality of antibacterials for type Ⅰ incision in two groups. Results: After the intervention, the application rate of anti-bacterial drugs in class Ⅰ incision surgery decreased by 20.35%, the third-generation cephalosporin application rate decreased by 41.26%, and the first-generation cephalosporin application rate increased by 11.67%. The time of initial medication was increased by 36.57% in 0.5 ~ 2 h before operation and 38.76% after 48 h. The difference was statistically significant (P <0.05). Conclusion: Our hospital can ensure rational and safe use of antimicrobial agents through effective interventions.