前列腺素(prostaglandins,PGs)是广泛存在于动物和人体内的一组重要的组织激素,它们调节中枢神经系统的许多功能。PGs不仅是炎症介质,还是一类重要的疼痛介质,它能敏化伤害性感受器和增强脊髓水平的疼痛信号,对疼痛外周敏化的形成起到重要作用。环氧化酶(cyclooxygenase,COX),? Prostaglandins (PGs) are a group of important tissue hormones widely found in animals and humans that regulate many functions of the central nervous system. PGs are not only inflammatory mediators but also an important class of pain mediators that can sensitize nociceptors and increase pain signals at the spinal level and play an important role in the sensitization of peripheral pain. Cyclooxygenase (COX) ,?