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有毒物质Hormesis效应对传统的毒理学模型提出了挑战。在低剂量条件下单纯的效应增强并不一定是Hormesis效应,可能由效应的某种波动或试验误差引起。对有毒物质Hormesis效应特征、发生的低剂量范围及其识别与评价方法进行了综述,并以低剂量镉对蚯蚓体内谷胱甘肽过氧化物酶(CSH-PX)活性影响为例,建立了Hormesis效应及其定量评价方法。结果表明,二次函数拟合模型为Y=0.3994-1.4472X~2+1.707X,刺激效应强度为45.34%。
The Hormesis effect of toxicants presents a challenge to traditional toxicology models. The mere increase of the effect at low doses is not necessarily the Hormesis effect and may be caused by some fluctuations in the effect or experimental error. The Hormesis effect characteristics of toxicants, the range of low dose occurred and the identification and evaluation methods of Hormesis were summarized. Taking the effect of low dose cadmium on the activity of glutathione peroxidase (CSH-PX) in earthworms as an example, Hormesis effect and its quantitative evaluation method. The results show that the quadratic function fitting model is Y = 0.3994-1.4472X ~ 2 + 1.707X, the stimulus effect intensity is 45.34%.