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将１５０例妊娠８～２８周要求药物流产的妇女随机分成２组：米非司酮和１５甲基ＰＧＦ２α（ＰＧ０５）阴道给药组（ｎ＝５０），米非司酮和米索前列醇口服给药组（ｎ＝１００）。观察其临床效果、孕周与流产效果及时间的关系、腹痛情况。结果：两组完全流产率分别为８４％和８８％，Ｐ＞０．０５，差异无显著性；按孕周分组１５～２８周组完全流产率为９２．４％，明显高于８～１４周组，流产所用时间长于８～１４周组，Ｐ＜０．０１，差异有显著性，两组无腹痛或轻微腹痛者约占８５％以上。结论：米非司酮配伍前列腺素引产安全、有效，有临床实用价值。
150 women who required medical abortion from 8 to 28 weeks of gestation were randomly assigned to 2 groups: vaginal administration of mifepristone and 15-methyl PGF2α (PG05) (n = 50), mifepristone and misoprostol Oral administration group (n = 100). Observe its clinical effect, gestational age and abortion effect and the relationship between time, abdominal pain situation. Results: The complete abortion rates of the two groups were 84% and 88%, respectively, P> 0.05, the difference was not significant; the complete abortion rate was 92.4% between 15 and 28 weeks gestation group, significantly higher than 8 to 14 Week group, abortion for longer than the 8-14 week group, P <0.01, the difference was significant, two groups of no abdominal pain or mild abdominal pain accounted for about 85%. Conclusion: Mifepristone combined with prostaglandin is safe and effective in induction of labor and has clinical value.