潘生丁在pH 3.3以上时难溶,关于在人胃液pH条件下,其pH值对潘生丁片生物利用度的影响还未见报告。作者用体外试验法对此进行了研究。采用9种市售糖衣片,编号为A、B、C、D、E、F、G、H、I。含量均匀性试验符合美国XX版药典。崩解试验符合日本X版药典, 其崩解时间均在2.2～11.8分钟。洛出试验采用美国XX版药典规定的方 Dipyridamole is poorly soluble above pH 3.3, and no reports have been reported on the effect of pH on the bioavailability of dipyridamole tablets at human gastric pH. The authors studied this in vitro. Nine commercial sugar-coated tablets are used, numbered A, B, C, D, E, F, G, H, I. Content uniformity test in line with the United States XX Pharmacopoeia. Disintegration test in line with the Japanese version X pharmacopoeia, the disintegration time are in 2.2 ~ 11.8 minutes. Los out of the test using the United States XX Pharmacopoeia prescription