非类固醇抗炎药简称NSAIDs,其药物动力学见附表。这类药由于缺少静脉用制剂,因此其生物可用度一般在很大程度上尚未能用数量表示出来。然而,我们可以肯定,因为它们都能很好地被吸收,临床上还没有出现由于药物间相互作用而影响生物可用度的现象。大多数NSAIDs的分布容积小,一般为人体重量的10％左右。分布容积小主要是血浆白蛋白结合率很高,大都在99％以上。因此,血浆中只有少量的药物。由于NSAIDs具有广谱的消除半衰期,其消除率变化较大。例如,酮洛芬和炎痛喜康分布容积非常接近,分别为0.11和0.12～0.15L/kg,但这两种药物的消除半衰期明显 Non-steroidal anti-inflammatory drugs referred to as NSAIDs, the pharmacokinetics of the schedule. Due to the lack of intravenous agents, the bioavailability of these drugs has not yet been quantified to a large extent. However, we can be sure, because both of them are well absorbed and there has not been clinically seen any effect on bioavailability due to drug-drug interactions. The distribution of most NSAIDs small volume, usually about 10% of body weight. Small volume of distribution is mainly high plasma albumin binding rate, mostly in more than 99%. Therefore, there is only a small amount of drug in the plasma. Due to the broad elimination half-life of NSAIDs, the elimination rate varies greatly. For example, ketoprofen and piroxicam have very similar volume distributions of 0.11 and 0.12 to 0.15 L / kg, respectively, but the elimination half-life of both drugs is significant