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目的:比较静脉注射帕瑞昔布钠(parecoxi-sodium)与氟比洛芬酯用于无痛人流术后镇痛的临床效果。方法:将ASAⅠ～Ⅱ、年龄19～47岁的拟行无痛人流手术者60例随机分为Ⅰ组30例术后静脉注射帕瑞昔布钠40 mg和Ⅱ组30例术后静脉注射氟比洛芬酯50 mg。观察术后疼痛强度(VAS评分)、不良反应和病人对镇痛的满意度。结果:与氟比洛芬酯组相比,帕瑞昔布钠组术后VAS评分降低(P<0.05),术后24 h满意度明显提高(P<0.05)。术后帕瑞昔布钠组不良反应发生率较氟比洛芬酯组明显降低,差异有统计学意义(P<0.05)。结论:无痛人流术后静脉给予帕瑞昔布钠40 mg镇痛效果优于静脉注射氟比洛芬酯50 mg,并可降低不良反应的发生率。
OBJECTIVE: To compare the clinical efficacy of intravenous injection of parecoxi-sodium and flurbiprofen axetil for analgesia after painless abortion. Methods: Sixty ASAⅠ ~ Ⅱ patients aged 19-47 years who were scheduled to undergo painless abortion were randomly divided into group Ⅰ (30 cases), intravenous injection of parecoxib (40 mg) and group Ⅱ (n = 30) Ibuprofen ester 50 mg. Postoperative pain intensity (VAS score), adverse reactions, and patient satisfaction with analgesia were observed. Results: Compared with flurbiprofen ester group, postoperative VAS score in Parecoxib group was decreased (P <0.05), and satisfaction at 24 h after operation was significantly improved (P <0.05). Postoperative parecoxib sodium adverse reaction rate than flurbiprofen ester group was significantly lower, the difference was statistically significant (P <0.05). CONCLUSION: The analgesic effect of intravenous injection of parecoxib 40 mg after intravenous painless surgery is superior to intravenous injection of flurbiprofen axetil 50 mg and can reduce the incidence of adverse reactions.