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在大鼠L5背根节浸浴钠通道失活门阻断剂藜芦碱 (veratridine) ,记录该背根节神经元A类单纤维传入放电。发现 :浸浴藜芦碱 (1 8～ 3μmol/L) 10min后 ,触压皮肤感受野或刺激坐骨神经引起部分静息纤维产生高频放电 ,其放电峰峰间期 (interspikeinterval,ISI)形成U字形等型式的振荡 ,称之为触发性振荡。刺激脉冲的间隔越大 ,触发该振荡所需要的刺激脉冲数也就越多 ;不同时程和形式的刺激引起触发性振荡的形式无明显差异 ;触发性振荡的后抑制时期一般为 30～ 90s。另外 ,实验还观察到该触发性振荡可由同一神经刺激引起的传入冲动触发。上述结果表明 ,用藜芦碱处理可使初级感觉神经元产生一种触发性振荡 ,该振荡机制可能与触发痛的发作有关。
In rat L5 dorsal root ganglion, a sodium channel inactivation gating inhibitor, veratridine was infused into the dorsal root ganglion to record the afferent discharge of type A monofilament of dorsal root ganglion neurons. After resveratrol (18 ~ 3μmol / L) was immersed for 10min, some rest fibers were exposed to skin sensory field or sciatic nerve to cause high frequency discharge. The interspikeinterval (ISI) Other types of oscillation, called the triggering oscillation. The larger the interval of stimulation pulse, the more the number of stimulation pulses required to trigger the oscillation; the different forms and duration of stimulation caused no significant difference in the form of the trigger oscillation; The period of post-suppression of trigger oscillation is generally 30 ~ 90s . In addition, it was also experimentally observed that this triggering oscillation could be triggered by an afferent impulse caused by the same neural stimulation. The above results indicate that treatment with veratridine produces a triggering oscillation in primary sensory neurons that may be involved in triggering the onset of pain.