目的:了解肾综合征出血热(HFRS)患者不同病期和病型TNF-α动态变化。方法:用ELISA检测32例HFRS患者血清TNF-α含量。结果:在不同病期的HFRS患者中,TNF-α在发热期已升高,低血压期明显升高,至少尿期达到高峰。在不同病型的HFRS患者中,随病情加重,TNF-α的含量与尿蛋白水平呈正相关。结论:动态检测HFRS患者血清TNF-α含量,对病情进展和疾病严重程度的判断有一定意义。 Objective: To understand the dynamic changes of TNF-α in different stages and types of patients with hemorrhagic fever with renal syndrome (HFRS). Methods: Serum levels of TNF-α in 32 patients with HFRS were detected by ELISA. Results: In different stages of HFRS patients, TNF-α in the fever has increased, low blood pressure increased significantly, at least the peak period of urine. In different types of HFRS patients, with the aggravation of the disease, the level of TNF-αwas positively correlated with urinary protein level. Conclusion: The dynamic detection of serum TNF-α levels in patients with HFRS is of certain significance for the judgment of disease progression and disease severity.