随着免疫学的进步,人们已认识到免疫机构可以通过淋巴细胞的多种途径调节机体的生理平衡.免疫现象是识别自己和非己的过程,而自身免疫就是机体对自身抗原的应答形式,故而成为研究免疫方面受到重视的一个问题.但是不可能用抗原刺激诱导自身抗体,在克隆水平上探求自身抗体的产生机制也极为困难.近年来由于细胞工程的应用,极大地促进了这些研究的进展. With the progress of immunology, it has been recognized that immune institutions can regulate the body’s physiological balance through various ways of lymphocytes.Immune phenomenon is the process of identifying oneself and oneself, while autoimmunity is the form of the body’s response to self-antigens, So it has become a problem to be studied in the field of immunology.However, it is impossible to induce autoantibodies by antigen stimulation and it is very difficult to search for the production mechanism of autoantibodies at the level of cloning .In recent years, due to the application of cell engineering, these studies have greatly promoted progress.