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目的研究血清B淋巴细胞刺激因子(Blys)在系统性红斑狼疮(SLE)中的意义。方法酶联免疫吸附试验(ELISA)法检测125例SLE患者血清Blys水平,并与狼疮活动程度和临床表现进行相关性分析。结果125例SLE患者血清平均Blys水平显著高于正常对照组[(0.72±0.18)ng,ml vs(0.34±0.10)ng/ml,P=0.0031];SLE患者血清平均Blys水平与SLE疾病活动指数(SLEDAI)积分呈一定程度相关性(r=0.73,P=0.018);SLE患者血清Blys水平与抗dsDNA抗体滴度呈正相关,而与血清IgG、补体、蛋白尿、白细胞、血小板计数,以及皮疹、关节痛、口腔溃疡、脱发、发热等临床表现等均无显著相关性(P>0.05)。结论SLE患者血清Blys水平升高,与狼疮活动呈一定相关性,但不能准确反映病变部位及严重程度。
Objective To study the significance of serum B lymphocyte stimulating factor (Blys) in systemic lupus erythematosus (SLE). Methods Serum Blys levels were measured by enzyme linked immunosorbent assay (ELISA) in 125 patients with SLE and their correlations were analyzed with the degree of lupus activity and clinical manifestations. Results The serum Blys levels in 125 patients with SLE were significantly higher than those in controls ([0.72 ± 0.18] ng / ml vs 0.34 ± 0.10 ng / ml, P = 0.0031]. The mean serum Blys levels in patients with SLE were significantly correlated with SLE disease activity index (R = 0.73, P = 0.018). There was a positive correlation between serum Blys levels and anti-dsDNA antibody titer in patients with SLE, but not with serum IgG, complement, proteinuria, white blood cells, platelet count, , Joint pain, oral ulcer, hair loss, fever and other clinical manifestations were no significant correlation (P> 0.05). Conclusion The level of Blys in patients with SLE is increased, which is correlated with lupus activity, but it can not accurately reflect the location and severity of the disease.