人体组织由细胞和细胞间基质组成,肿瘤也不例外。除了肿瘤细胞之外,肿瘤还含有血管、结缔组织等基质。目前,常规对肿瘤样品基因表达量的研究实际上是对肿瘤细胞和基质混合物的研究。基质细胞往往没有癌变,因此对肿瘤细胞和基质混合物进行研究往往会掩盖掉肿瘤细胞中并不是很明显的基因表达异常。 Human tissue consists of cells and intercellular matrix, the tumor is no exception. In addition to tumor cells, tumors also contain blood vessels, connective tissue and other substrates. At present, the conventional study of the gene expression level of tumor samples is actually a study on the mixture of tumor cells and matrix. Stromal cells are often not cancerous, so a study of tumor cells and matrix mixtures often masked abnormal gene expression that was not apparent in tumor cells.