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本文研究了二巯基丁二酸(DMSA)和二巯基丙磺酸钠(DMPS)口服给药治疗路易氏剂中毒的疗效以及口服DMSA后的吸收及排泄情况。实验证明,中毒后立即口服DMSA或DMPS 0.5mmol/kg可分别使小鼠皮下注射路易氏剂的LD_(50)从2.54mg/kg提高为15.61mg/kg和8mg/kg,接近该二药注射给药所达到的疗效。口服DMSA对抗小鼠路易氏剂LD_(100)剂量(3.5mg/kgs.c.或用,SC)中毒的ED_(50)为0.03mmol/kg,比注射给药的ED_(50)值稍高;口服DMPS对抗小鼠路易氏剂LD_(100)剂量中毒的ED_(50)为0.17mmol/kg,大约是注射给药ED_(50)值的三倍。在大鼠皮下注射路易氏剂1.5mg/kg后立即、6h、24h和48h后分别口服DMSA或DMPS 0.5mmol/kg可显著增加尿中砷的排泄,给药后第一天砷排泄量最大。通过测定大鼠口服DMSA后尿中巯基的排泄证实DMSA在胃肠道内的吸收良好,排泄速度低于静脉注射给药。
This article studies the efficacy of oral administration of dimercaptosuccinic acid (DMSA) and sodium dimercaptopropanesulfonate (DMPS) in the treatment of Rehmannia poisoning and the absorption and excretion of oral DMSA. Experiments show that oral administration of DMSA or DMPS 0.5 mmol / kg immediately after poisoning can increase the LD50 of mice injected with Lewis agent from 2.54 mg / kg to 15.61 mg / kg and 8 mg / kg, respectively, The efficacy achieved by the administration. The ED50 of oral DMSA against LDL (100 mg) dose (3.5mg / kgs.c. or SC) in mice was 0.03mmol / kg, which was slightly higher than that of ED50 ; ED50 of oral DMPS against Lewis Reagent LD_ (100) dose was 0.17 mmol / kg, which was about three times that of ED_ (50). Administration of 0.5 mmol / kg DMSA or DMPS 6 h, 24 h and 48 h after Lewis subcutaneous injection of 1.5 mg / kg of Lewis agents significantly increased urinary excretion of arsenic, with the largest amount of arsenic excreted on the first day after administration. DMSA in rats by measuring the urinary excretion of thiol after DMSA confirmed the absorption of good gastrointestinal tract, excretion rate lower than intravenous administration.