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目的探讨保护性通气联合乌司他丁治疗急性呼吸窘迫综合征(ARDS)患者的效果。方法将60例ARDS患者随机分为对照组和乌司他丁组,均常规进行肺保护性机械通气(最佳PEEP加潮气量5～8 ml/kg)。对比两组治疗有效率及治疗前后血气分析变化,并记录住重症监护病房(ICU)时间、住院时间、死亡率等指标以比较其预后。结果保护性通气联合乌司他丁治疗有效率达90%,与对照组60%相比差异有统计学意义(P<0.01);乌司他丁组PaO2、氧合指数高于对照组,差异有统计学意义(P<0.01),乌司他丁组住ICU时间、住院时间显著短于对照组,死亡率低于对照组。结论保护性通气联合乌司他丁治疗ARDS有助于改善患者的呼吸功能及预后。
Objective To investigate the effect of protective ventilation combined with ulinastatin in the treatment of patients with acute respiratory distress syndrome (ARDS). Methods Sixty patients with ARDS were randomly divided into control group and ulinastatin group. All patients underwent routine protective mechanical ventilation (optimal PEEP plus tidal volume 5-8 ml / kg). Compare the two groups of treatment efficiency and blood gas analysis before and after treatment changes, and recorded the ICU time, hospital stay, mortality and other indicators to compare their prognosis. Results The protective ventilation combined with ulinastatin had an effective rate of 90%, which was significantly different from that of the control group (P <0.01). PaO2 and oxygenation index in ulinastatin group were higher than those in control group (P <0.01). The ICU time and hospitalization time of ulinastatin group were significantly shorter than that of control group, and the mortality rate was lower than that of control group. Conclusion Protective ventilation combined with ulinastatin can improve respiratory function and prognosis of patients.