GR43175,即3-{2-(二甲氨基)乙基}-N-甲基-IH-吲哚-5-甲烷-磺胺,是一种新的5-HT_1样受体激动剂。动物实验证明对颈循环的动静脉吻合支有选择性收缩作用。作者首次报告用GR43175静注治疗急性偏头痛发作的临床效果。材料本组34例(46次发作),女32例,男2例。年龄20～59(平均39.6)岁。除1例为典型偏头痛外,其余均为普通型偏头痛。根据头痛程度分为Ⅰ、Ⅱ、Ⅲ度。Ⅰ度为轻度头痛,Ⅱ度为中度头痛,Ⅲ度为重 GR43175, a novel 5-HT1-like receptor agonist, is 3- {2- (dimethylamino) ethyl} -N-methyl-1H-indole-5-methane-sulfonamide. Animal experiments show that the arterial and venous anastomosis of the cervical circulation has a selective contraction. The authors report for the first time the clinical efficacy of GR43175 for the treatment of acute migraine attacks. Materials 34 cases (46 episodes), 32 females, 2 males. Age 20 ~ 59 (average 39.6) years old. Except 1 case of typical migraine, the rest are common type of migraine. According to the degree of headache is divided into Ⅰ, Ⅱ, Ⅲ degrees. Degree I was mild headache, degree II was moderate headache, degree III was heavy