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目的观察敷和备化方联合雷火灸治疗原发性肝癌介入术后综合征的临床疗效。方法选取80例行TACE治疗的原发性肝癌患者,随机方法将病人分为两组:治疗组予以敷和备化方联合雷火灸治疗配合西医对症处理,对照组仅予以西医对症处理。观察患者治疗前后症状、肝功能指标(碱性磷酸酶、门冬氨酸氨基转移酶、丙氨酸氨基转移酶)、治疗前后行为状态Karnofsky评分分级、AFP及VEGF的变化。结果治疗组对发热、恶心呕吐、腹胀、黄疸、胁痛等症状的改善优于对照组(P<0.05);肝功能损害,治疗组较对照组轻(P<0.05);行为状态Karnofsky评分比较,治疗组优于对照组(P<0.05);治疗疗程后甲胎蛋白及VEGF含量,治疗组低于对照组(P<0.05)。结论敷和备化方联合雷火灸治疗治疗原发性肝癌介入术后综合征,能有效改善患者发热、恶心呕吐、腹胀、黄疸、胁痛等症状,改善肝功能指标,提高患者术后的生活质量;同时降低因肿瘤原因升高的AFP及VEGF含量,具有抑制肿瘤新生血管形成,降低肝癌复发和转移率的作用。
Objective To observe the curative effect of Fuhehuixuefang combined with Leihuo moxibustion in the treatment of post-PCI syndrome of primary liver cancer. Methods Eighty patients with primary hepatocellular carcinoma treated with TACE were randomly divided into two groups: the treatment group was treated with Radix Moxibustion combined with Western medicine, and the control group was treated with Western medicine only. The symptoms of patients before and after treatment, liver function indicators (alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase), before and after treatment Karnofsky grading, AFP and VEGF changes. Results The improvement of symptoms such as fever, nausea, vomiting, abdominal distension, jaundice, hypochondriac pain in treatment group was better than that in control group (P <0.05); liver function impairment was lighter in treatment group than in control group (P <0.05); Karnofsky score (P <0.05). The content of alpha-fetoprotein and VEGF in the treatment group was lower than that in the control group (P <0.05). Conclusion Fu-Hebian Recipe combined with thunderstorm moxibustion treatment of post-PCI interventional syndrome can effectively improve the symptoms such as fever, nausea and vomiting, abdominal distension, jaundice, hypochondriac pain, improve the liver function index and improve the postoperative life Quality; at the same time reduce the elevated AFP and VEGF levels due to tumor causes, inhibit tumor angiogenesis, reduce the recurrence and metastasis of liver cancer.