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为了探讨输精管吻合术后不育家兔的血清睾酮 (T)、雌二醇 (E2 )的变化与血清白细胞介素 1(IL 1)活性、肿瘤坏死因子α(TNFα)含量的相关性 ,在复制输精管吻合模型的基础上 ,根据生育能力恢复与否分为吻合育组(VFG)、吻合不育组 (VIG) ,另设同龄输精管结扎组 (VG)和假手术组 (SOG)作为对照。结果表明 :(1)血清睾酮含量VIG显著低于VFG和SOG ,VFG显著高于SOG、VG和VIG。 (2 )血清雌二醇含量 ,各组间无显著差异。但是E2 /T比值差异显著 ,以VIG为最高 ,VFG为最低。 (3)IL 1活性VIG显著地高于SOG和VFG。TNFα含量VIG极为显著地高于其他 3组。 (4 )相关检验表明 ,血清IL 1活性、TNFα含量与睾酮含量均呈明显的负相关关系 ;与E2 /T比值呈明显的正相关关系
In order to investigate the relationship between the changes of serum testosterone (T) and estradiol (E2) and the activity of serum IL-1 and tumor necrosis factor α (TNFα) in sterilized rabbit after anastomosis of vas deferens, According to the anastomosis model of reproductive vas deferens, VFG, VG, VG and SOG were used as controls according to whether fertility was restored or not. The results showed that: (1) serum testosterone content VIG was significantly lower than VFG and SOG, VFG was significantly higher than SOG, VG and VIG. (2) Serum estradiol levels, no significant difference between the groups. However, the difference of E2 / T ratio was significant, with VIG as the highest and VFG as the lowest. (3) IL 1 activity VIG was significantly higher than SOG and VFG. The Vα content of TNFα was significantly higher than the other three groups. (4) The correlation test showed that serum IL 1 activity, TNFα content and testosterone content showed a significant negative correlation; and E2 / T ratio was significantly positive correlation