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目的:研究免疫共刺激分子CD40在结肠癌及癌旁组织中的表达情况及其生物学意义。方法:应用免疫组织化学技术检测65例结肠癌组织和10例癌旁组织中CD40蛋白的表达,并分析CD40表达水平与临床病理特征的相关性。结果:免疫组织化学检测结果显示,CD40蛋白阳性染色于细胞膜和细胞质,在结肠癌组织中高表达率为41.5%,而在正常癌旁组织中不表达,差异有统计学意义(P<0.05)。CD40蛋白表达与肿瘤TNM分级和淋巴结转移显著相关(P<0.05),与患者年龄、性别及肿瘤大小无相关性(P>0.05)。结论:CD40分子可能在结肠癌发病过程中起重要作用,可作为结肠癌预后判断及淋巴结转移监测的有价值的指标之一。
Objective: To study the expression of immunostimulatory molecule CD40 in colorectal carcinoma and its adjacent tissues and its biological significance. Methods: The expressions of CD40 protein in 65 cases of colon cancer and 10 cases of paracancerous tissues were detected by immunohistochemistry. The correlation between the expression of CD40 and clinicopathological features was analyzed. Results: The results of immunohistochemistry showed that the positive expression of CD40 protein in the cell membrane and cytoplasm was 41.5% in the colorectal cancer tissues, but not in the normal paracancerous tissues (P <0.05). The expression of CD40 protein was significantly correlated with TNM classification and lymph node metastasis (P <0.05), but not with age, sex and tumor size (P> 0.05). Conclusion: CD40 may play an important role in the pathogenesis of colon cancer and may be used as a valuable indicator for the prognosis of colon cancer and monitoring of lymph node metastasis.