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本文观察了败酱科植物糙叶败酱(Patrinia scabra Bunge)根和根茎中制得的挥发油的镇静作用,井与黄花败酱挥发油做了比较。结果表明,此油灌胃给予数组小鼠,剂量0.45ml/kg,显示如下的作用:[1]能显著延长由于腹腔注射戊巴比妥钠(50mg/kg)引起的小鼠睡眠时间,但其作用强度弱于黄花败酱挥发油。(2)一次灌胃给予小鼠大剂量10.46g/kg的糙叶败酱挥发油,连续观察10天,动物外观正常,无一死亡,体重增加与对照组相似。
In this paper, the sedative effect of the volatile oils obtained from the roots and rhizomes of Patrinia scabra Bunge was observed. The wells were compared with the volatile oils of P. bracteatum. The results showed that the mice were administered intragastrically to an array of mice at a dose of 0.45 ml/kg, which showed the following effects: [1] can significantly prolong the sleep time of mice caused by intraperitoneal injection of sodium pentobarbital (50 mg/kg), but Its strength is weaker than the volatile oil of Prunus vulgaris. (2) Mice were given a large dose of 10.46g/kg volatile oil of Prunella vulgaris by gavage for 10 days. The animals were normal in appearance, and none of them died. The weight gain was similar to that of the control group.