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目的:观察早期使用比索洛尔对急性心肌梗死(AMI)患者心率振荡现象的影响。方法:将我院2007-08-2008-08期间住院的AMI患者100例,相应分为比索洛尔组和对照组;利用24 h动态心电分析系统获得其室性期前收缩,分别计算2组治疗前及治疗2周后的振荡初始(TO)和振荡斜率(TS)2个指标。结果:治疗前2组TO值和TS值均异常,但组间差异无统计学意义(P>0.05),治疗后与同组治疗前比较,TO值和TS值差异均有统计学意义(P<0.05),与对照组比较,治疗后比索洛尔组TO值显著降低,TS值显著升高(均P<0.01)。结论:早期使用比索洛尔可以有效改善AMI患者心率振荡现象,降低猝死风险。
Objective: To observe the effect of early use of bisoprolol on heart rate oscillations in patients with acute myocardial infarction (AMI). Methods: 100 cases of AMI patients hospitalized in our hospital from 2007-08-2008-08 were divided into bisoprolol group and control group. The ventricular premature contractions were obtained by 24 h dynamic electrocardiogram analysis system, respectively Two indexes of oscillation initial (TO) and oscillation slope (TS) before treatment and after 2 weeks of treatment were observed. Results: Before treatment, the values of TO and TS were abnormal, but there was no significant difference between the two groups (P> 0.05). After treatment, the values of TO and TS were significantly different (P <0.05). Compared with the control group, the TO value in the bisoprolol group was significantly decreased and the TS value was significantly increased (all P <0.01). Conclusion: Early use of bisoprolol can effectively improve the heart rate oscillations in AMI patients and reduce the risk of sudden death.