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茶碱为1.3—二甲黄嘌呤,与咖啡因同属嘌呤类药物。有利尿兴奋心脏和胃以及松驰平滑肌的作用,据认为后一作用是由于抑制磷酸二酯酶,使3′,5′—环磷酸腺甙的含量增加所致,主要适用于治疗气道阻塞及急性左心衰竭,还可用于治疗胆及尿道绞痛。茶碱在临床上应用比较广泛,主要用于平喘,由于其有效浓度为10～20毫克/升,安全范围窄、代谢的个体差异大,任何影响其浓度的因素均可影响其疗效,其中主要是受药物不良相互作用影响,可引起严重的不良反应,甚至造成死亡。目前临床常用的氨茶碱是茶碱和乙二胺的复合物,推测其在药物相互
Theophylline is 1.3-dimethylxanthine, and caffeine are the same purine drugs. A diuretic excited heart and stomach and the role of relaxation of smooth muscle, it is thought that the latter effect is due to inhibition of phosphodiesterase, the 3 ’, 5’-cyclic AMP content, mainly for the treatment of airway obstruction And acute left heart failure, but also for the treatment of gall bladder and urethral colic. Theophylline is widely used clinically, mainly for asthma, due to its effective concentration of 10 ~ 20 mg / L, narrow safety range, the individual differences in metabolism, any factors that affect its concentration can affect its efficacy, of which Mainly affected by adverse drug interactions, can cause serious adverse reactions, and even cause death. At present, the commonly used aminophylline is theophylline and ethylenediamine complex, speculated that the drug mutual