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目的：探讨自身抗体在复发性阿弗它口炎（ＲＡＳ）伴发上消化道疾病中的作用．方法：选择４５例已确诊伴有上消化道疾病（ＵＡＴＤ）的ＲＡＳ患者（简称ＲＡＳ－ＵＡＴＤ），采用间接免疫荧光法（ＩＦ）观察其循环血液中抗口腔粘膜抗体（ＡＯＭＡ）及抗胃壁细胞抗体（ＡＳＭＡ）的存在情况，设健康对照组比较，做出相关性分析．结果：ＲＡＳ－ＵＡＴＤ患者中ＡＯＭＡ及ＡＳＭＡ阳性率分别达８６．６７％和７１．１１％，两者间无显著性差异（ｐ＞０．０５），与健康对照组比较有非常显著性差异（ｐ＜０．００１）．结论：自身循环抗体ＡＯＭＡ及ＡＳＭＡ所引发的抗原——抗体反应以及它们之间的部分交叉免疫反应，可能是造成ＲＡＳ患者多发上消化道疾病（ＵＡＴＤ）的重要因素．
Objective: To investigate the role of autoantibodies in recurrent aphthous stomatitis (RAS) associated with upper gastrointestinal diseases. METHODS: Forty-five RAS patients (RAS-UATD) who had been diagnosed with upper gastrointestinal disease (UATD) were enrolled in this study. Apoptotic anti-oral mucosal antibodies (AOMA) and gastric parietal cells were measured by indirect immunofluorescence staining Antibody (ASMA), the existence of healthy control group were compared to make a correlation analysis. Results: The positive rates of AOMA and ASMA in patients with RAS-UATD were 86.67% and 71.11%, respectively, with no significant difference (p> 0.05), which were significantly different from those in healthy controls p <0.001). Conclusion: The antigen-antibody responses induced by autoantibodies AOMA and ASMA, as well as the partial cross-immune responses between them, may be important factors in the pathogenesis of multiple upper gastrointestinal diseases (UATD) in patients with RAS.