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目的探讨枸橼酸莫沙必利联合护理干预对2型糖尿病胃轻瘫患者胃动力改变的影响。方法选择2014年4月-2015年8月医院收治的2型糖尿病胃轻瘫患者70例,随机分为观察组和对照组各35例,给予2组患者均进行常规的基础降糖治疗,对照组在此基础上加用枸橼酸莫沙必利进行治疗,观察组则在对照组基础上联合护理干预进行治疗,2组患者均治疗4周。治疗结束后观察2组患者的胃动力变化情况。结果治疗后,观察组液相GET1/2为(41.34±10.22)min、固相GET1/2为(70.65±10.15)min,明显的低于对照组液相GET1/2(48.32±10.43)min、固相GET1/2(77.04±13.75)min;治疗后观察的血清胃泌素水平为(86.02±27.64)pg/ml、血浆胃动素为(541.43±56.04)pg/ml,明显的低于对照组血清胃泌素水平(106.18±30.53)pg/ml、血浆胃动素(575.17±60.25)pg/ml,观察组的生长抑素水平(49.73±11.21)pg/ml明显的高于对照组的生长抑素水平(44.11±12.04)pg/ml,差异有统计学意义(P<0.05)。结论枸橼酸莫沙必利联合护理干预治疗2型糖尿病胃轻瘫能够显著的改善患者的胃排空时间,提高其生长抑素的水平,同时降低患者血清胃动素与血浆胃动素,显著改善其胃动力。
Objective To investigate the effect of mosapride citrate combined nursing intervention on gastric motility in patients with type 2 diabetic gastroparesis. Methods Seventy patients with type 2 diabetes mellitus with gastroparesis admitted from April 2014 to August 2015 in our hospital were randomly divided into observation group and control group with 35 cases each. The patients in both groups were given routine basic hypoglycemic treatment. On the basis of this group, mosapride citrate was used for treatment. The observation group was treated on the basis of the control group with nursing intervention, and both groups were treated for 4 weeks. After treatment, the changes of gastric motility in two groups were observed. Results After treatment, the number of GET1 / 2 in the observation group was (41.34 ± 10.22) min and that in the solid phase was (70.65 ± 10.15) min, which was significantly lower than that of the control group (GET1 / 2, 48.32 ± 10.43) The serum gastrin level was (86.02 ± 27.64) pg / ml and plasma motilin was (541.43 ± 56.04) pg / ml, which was significantly lower than that of the control The levels of serum gastrin (106.18 ± 30.53) pg / ml, plasma motilin (575.17 ± 60.25) pg / ml and the somatostatin level in the observation group (49.73 ± 11.21) pg / ml were significantly higher than those in the control group Somatostatin level (44.11 ± 12.04) pg / ml, the difference was statistically significant (P <0.05). Conclusion Mosapride Citrate combined with nursing intervention for type 2 diabetic gastroparesis can significantly improve the patient’s gastric emptying time and improve the level of somatostatin, while reducing the serum motilin and plasma motilin, Significantly improved gastric motility.