氧化苦参碱是自中药苦参中提取的一种生物碱,本文就其对小鼠肝微粒体药物代谢酶的影响进行了探讨。结果表明,氧化苦参碱(100mg/kg)能缩短小鼠戊比妥钠睡眠时间,提高肝微粒体细胞色素 P-450含量并增强乙基吗啡 N-脱甲基酶对硝基茴香醚 O-脱甲基酶和苯并芘羟化酶的的活性,形态上使肝细胞滑面内质网增生。以上结果说明,氧化苦参碱是细胞色素 P-450的诱导剂。 Oxymatrine is an alkaloid extracted from the traditional Chinese medicine Sophora flavescens. In this paper, the effect of its on the metabolism enzyme of mouse liver microsomes is discussed. The results showed that oxymatrine (100mg/kg) can shorten the sleep time of pentobarbital in mice, increase the content of hepatic microsomal cytochrome P-450 and enhance the ethylmorphine N-demethylase p-nitroanisole O - The activity of demethylase and benzofluorene hydroxylase morphologically promotes the proliferation of endoplasmic reticulum in hepatocytes. The above results indicate that oxymatrine is an inducer of cytochrome P-450.