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羊踯躅Rhododendron molle G、Don为杜鹃花科植物,其干燥果实中存在着除梫木毒素外的其它镇痛成分,定名为八厘麻A。嗣后,我们又从其干燥花即闹羊花中,分离到四个成分:Rd-Ⅰ、Rd-Ⅱ、Rd-Ⅲ、Rd-Ⅳ,经药理实验证明Rd-Ⅱ有较强的镇痛和镇静作用,安全范围也比较宽,试图为中药复合麻醉寻找新镇痛药。 方法与结果 一、镇痛实验 1.热板法:取体重在18～22克的雌性小白鼠,用浴温控制在55±0.1℃的超级恒温水浴,进行痛觉测定,以舐后足为痛疼反
Rhododendron molle G, Don is a rhododendron plants, its dried fruit in addition to aloe vera in addition to other analgesic ingredients, known as eight centimeter A. Subsequently, we also separated four components from their dried flowers, Aronia: Rd-Ⅰ, Rd-Ⅱ, Rd-Ⅲ and Rd-Ⅳ. Pharmacological experiments showed that Rd-Ⅱ has strong analgesic and Sedative effect, the scope of security is also relatively wide, trying to find new analgesics for traditional Chinese medicine compound anesthesia. Methods and Results 1. Analgesic Experiment 1. Hot Plate Method: Female mice weighing 18-22 g were treated with a bath of warm water in super thermostatic water bath at 55 ± 0.1 ° C for analgesia and pain in the hind foot Painful