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本文报告了葛根浸膏具有较为广泛而显著的β-受体阻滞效应。且对β_1-受体的作用强于β_2-受体。 相当于0.5～5mg/ml或750mg/kg的葛根能分别对抗异丙肾上腺素0.17～1.7μg/ml或10μg/kg诱发的离体或在体心脏的兴奋作用。此外,相当于750mg/kg的葛根除能阻滞10μg/kg异丙肾上腺素及肾上腺素舒血管(β-受体效应)所致的降压作用外,尚能降低正常心率(平均下降43.7％)及血压(平均下降40±6mmHg)的作用,这些结果为葛根用来缓解心绞痛,治疗快速型心律失常及高血压等提供了根据。 将葛根(750mg/kg)与心得宁(0.1mg/kg)抗异丙肾上腺素(10μg/kg)所致的β-受体效应加以比较,表明两者作用大体相似,减慢心率的作用心得宁似乎稍强于葛根。降压作用葛根略优于心得宁,且葛根无明显的抑制心脏的作用。 根据上述事实,可以认为葛根是一种有效的β-受体阻滞剂。
This article reports Pueraria extract has a more extensive and significant β-receptor block effect. And the role of β_1-receptor stronger than β_2-receptor. Puerariae, equivalent to 0.5-5 mg / ml or 750 mg / kg, were able to counteract the excitotoxic effects of isoprenaline, 0.17-1.7 μg / ml or 10 μg / kg, in vitro or in vivo, respectively. In addition, Puerariae, which is equivalent to 750 mg / kg, was able to reduce the normal heart rate (mean drop of 43.7%) in addition to the antihypertensive effect of 10 μg / kg of isoprenaline and adrenergic vasodilator (β-receptor effect) ) And blood pressure (mean 40 ± 6 mmHg). These results provide a basis for puerarin to relieve angina pectoris, to treat tachyarrhythmia and hypertension. The comparison of β-receptor effects induced by Puerarin (750mg / kg) and propranolol (0.1mg / kg) with isoproterenol (10μg / kg) showed that the effects of both were similar and their heart rate was slowed down Ning seems slightly stronger than Pueraria. Pueraria antihypertensive effect is slightly better than the experience Ning, and Pueraria no significant inhibition of the role of the heart. Based on the above facts, it can be considered that pueraria is a potent β-blocker.