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在160例代谢综合征患者和90例对照者,应用发色底物法测定血浆纤溶酶原激活物抑制物1(PAI1)活性和以PCR对PAI14G/5G多态位点的基因型进行检测。结果显示,PAI1活性升高是代谢综合征患者的特征之一,4G等位基因、血糖、甘油三酯与PAI1活性升高有关。
In 160 patients with metabolic syndrome and 90 controls, PAI1 activity was assayed by chromogenic substrate assay and the genotype of PAI14G / 5G polymorphism was detected by PCR . The results showed that PAI1 activity is one of the characteristics of patients with metabolic syndrome, 4G allele, blood glucose, triglycerides and PAI1 activity.