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目的:探讨血清脂联素及高分子量脂联素浓度随冠状动脉(冠脉)粥样硬化性斑块构成变化而变化的现象,为进一步研究影响冠脉斑块易损性的机制提供依据。方法:选取急性冠脉综合征(ACS)患者60例,运用酶联免疫分析法(ELISA)检测血清脂联素及高分子量脂联素的浓度。结合ST段及T波发生改变的导联,室壁运动异常的节段,复杂病变的部位及斑块破裂与否来综合确定罪犯病变。研究ACS患者血清脂联素及高分子量脂联素浓度与罪犯病变罪犯病变虚拟组织学-血管内超声(VH-IVUS)特点的相关性。结果:ACS患者血清高分子量脂联素与罪犯病变纤维脂质体积绝对值呈中等程度相关(r=0.505,P<0.01),与罪犯病变纤维组织体积绝对值亦呈正相关(r=0.499,P<0.01),而ACS患者血清脂联素与罪犯病变4种VH-IVUS检测的成分间无相关性。结论:ACS患者罪犯病变斑块相对稳定的成分纤维组织和纤维脂质含量增加时,血清高分子量脂联素也增加。高分子量脂联素作为保护性的脂肪因子可能参与到影响冠脉斑块易损性的机制。
Objective: To investigate the changes of serum adiponectin and high-molecular-weight adiponectin with the composition of atherosclerotic coronary arteries (coronary artery), and to provide basis for further study on the mechanism of the vulnerability of coronary plaque. Methods: Sixty patients with acute coronary syndrome (ACS) were selected. Serum adiponectin and high-density adiponectin were detected by enzyme-linked immunosorbent assay (ELISA). Combined with the ST segment and T wave lead changes, abnormal wall segments, complex lesions and plaque rupture or not to determine the culprit lesions. To study the correlation between serum adiponectin and high-molecular-weight adiponectin levels in ACS patients and the characteristics of virtual lesion-vascularization (VH-IVUS) in culprit lesions. Results: The serum adiponectin levels in ACS patients were moderately correlated with the absolute lipid volume of criminals (r = 0.505, P <0.01), and also positively correlated with the absolute value of crimson lesion fiber volume (r = 0.499, P <0.01). However, serum adiponectin levels in ACS patients were not correlated with those of the four VH-IVUS tests in culprit lesions. Conclusion: Serum high molecular weight adiponectin is also increased when the content of fibrous tissue and fiber lipid in the relatively stable plaques of criminals with ACS is increased. High molecular weight adiponectin as a protective adipokine may be involved in the mechanism of affecting the vulnerability of coronary plaque.